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Enzalutamide was developed by ligand-based drug design, which relied on the pharmacophores of known drugs, to bind and inhibit the AR with a much improved binding affinity (IC 50 =21 nmol/L, compared with 160 nmol/L for bicalutamide) 162
10.15585/mmwr.mm6606a1 124
Moreover, as mitochondria play a central strategic role in the activation and mode of cell death, mitochondrial GSH has been shown to critically regulate the level of sensitization to secondary hits that induce mitochondrial membrane permeabilization and release of proteins confined in the intermembrane space that once in the cytosol engage the molecular machinery of cell death
FatonaOOpasholaKFaleyeAAdeyanjuTAdekanmbiAEtiubonEet alGastroschisis in sub-saharan Africa: a scoping review of the prevalence, management practices, and associated outcomes
Kay SR, Fiszbein A, Opler LA
doi:10.1017/S0022215115000808
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