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Extracellular Matrix Synthesis In fibroblast culture, GHK-Cu has been reported to stimulate collagen synthesis, with the effect beginning in the picomolar range and maximising at 1 nM, independent of any change in cell number

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Studies show that higher IGF-1 bioavailability, measured by the IGF-1 to IGFBP3 ratio, is associated with lower perceived age and reduced skin wrinkling