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Strategies to address kidney function recovery to improve metabolism or oxidative stress must also address these within the liver

Including this regulatory process, the US FDA also considers other factors for approving a new drug or product: the drugs intended use and current treatment field, benefit-risk assessment based on well-designed clinical trials, and evaluating uncertainties or incomplete data

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A larger study (SEMA-NASH) enrolling 320 individuals with obesity, biopsy-proven NASH and different degrees of fibrosis, with or without diabetes, demonstrated that OD subcutaneous semaglutide 0.4 mg significantly resolved MASH without worsening fibrosis in 59% of patients 93

2l) but did not affect insulin secretion (Fig