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Many people carry stress in their upper trapezius muscles, leading to chronic tightness and pain

Science 376 , eabl4896 (2022)

Changes in the concentrations of plasma selenium and selenoproteins after minor elective surgery: further evidence for a negative acute phase response

This may trigger inflammation and play a role in autoimmune disease symptoms

demonstrated that lyso-Gb3 both at mild and more severe classical phenotype levels led to increased protein ubiquitination, suggesting that Lyso-Gb3 as well as Gb3 accumulation causes ER stress, a feature of the UPR (74)

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