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Clonidine helps opioid withdrawal, buprenorphine reduces cravings, diazepam prevents alcohol seizures, and nicotine replacement eases cigarette withdrawal

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Smoking also induces expression of immune checkpoint proteins like PD-L1 on tumor cells, which inhibit the activity of cytotoxic T lymphocytes by engaging PD-1 receptors, leading to immune exhaustion

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Students believed that waterpipe smoking was less harmful because there is little or no nicotine, there are fewer chemicals, and water filters the smoke [50]