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There's no benefit to mega-dosing, since your body regulates carnitine levels and excess isn't more effective

Notably, genes promoting glutathione biosynthesis were broadly upregulated, whereas genes associated with glutathione consumption or turnover were comparatively reduced ( Figure 6B )

Clin Pharmacol Ther 90:707711 Wynne HA, Cope LH, Herd B, Rawlins MD, James OF, Woodhouse KW (1990) The association of age and frailty with paracetamol conjugation in man

However, this doesn't necessarily mean it will kick-start detoxification

Subclinical atherosclerosis in systemic lupus erythematosus and antiphospholipid syndrome: focus on beta2GPI-specific T cell response