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NEVER Freeze the Liquid: While freezing the powder is good, freezing the liquid solution is bad

Wagenmakers (1998) reported that glutamine may act to modify the citric acid cycle (the main energy producing pathway or furnace in muscle mitochondria) in glycogen depleted muscle, by supplying fragments to the cycle, which in turn may enhance fatty acid oxidation (13) Anything that increases fatty acid burning should in theory at least help an athlete produce more energy and act to spare precious muscle glycogen

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Some of those include metformin which is used in type 2 diabetes, heartburn medications that alter the production of stomach acid such as PPIs or H2 blockers, and oral contraceptives