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However, no small-molecule GLP-1R agonist is available

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or if they develop signs of more serious adverse effects such as severe abdominal pain (which may indicate pancreatitis), symptoms of gallbladder disease, visual changes, severe allergic reactions, or symptoms of thyroid nodules

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However, several statistically significant associations emerged when comparing these agents against traditional anti-obesity medications across different BMI categories

[12] [13] mhra.gov.uk