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Retatrutide Phase 3 TRIUMPH-4 (NCT05931367, 445 participants, 68 weeks) reported 28.7% body weight loss at 12 mg, 26.4% at 9 mg, vs 2.1% placebo

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For research institutions designing protocols, this context is essential: the compounds therapeutic potential is supported by a large body of animal research, but translation to human outcomes remains an active area of investigation rather than established clinical fact

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We used Metascape to conduct a multiple database (including GO Biological Processes, KEGG Pathway, a Reactome gene set and WikiPathways) enrichment analysis, and construct a PPI network