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Mechanistically, STAT6 mediates transcriptional repression of peroxisome proliferator-activated receptor and its downstream fatty acid oxidation-related genes, culminating in lipid accumulation within RTECsa metabolic perturbation that drives fibrotic progression (Youjing et al., 2023)

So that tension between the Fed's delay to get ahead of the curve and the market's need for speed to get there sooner and more deliberately is where we think that, you know, we have to wait for that to occur to get the full rotation to the lower quality, kind of really cyclical parts of the market

It also promotes hepatic glucose output (which is carefully balanced by the insulin-stimulating effects of GLP-1 and GIP)

B., Khorasani, N

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doi: 10.1128/mcb.16.1.19