While animal models have demonstrated the therapeutic potential of metabolites, clinical translation is still hindered by pathological complexity and limited understanding of the metabolic effects of current interventions
Methods Eligibility criteria The PICOS strategy was defined as follows: P (participants) human subjects, I (interventions) oral LC treatment, C (comparisons) between supplementation and placebo, supplementation and control, or pre- and post- supplementation, O (outcomes) muscle variables, and S (study design) randomized controlled trials, non-randomized controlled trials, non-randomized non-controlled trials
Musculoskeletal Pain and Fibromyalgia Symptoms: Chronic pain in ME/CFS and Long COVID is often linked to localized cellular energy deficits and oxidative stress in muscle tissues
10.1007/s00125-007-0605-4
Magn Reson Med 74:15301542 Demarest TG, Schuh RA, Waddell J, McKenna MC, Fiskum G (2016) Sex dependent mitochondrial respiratory impairment and oxidative stress in a rat model of neonatal hypoxic-ischemic encephalopathy
Zhao J, Brault JJ, Schild A, Cao P, Sandri M, Schiaffino S, Lecker SH, Goldberg AL
