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The basic idea is that fecal matter builds up in the colon and leads to autointoxication, which is "an ancient theory based on the belief that intestinal waste products can poison the body and are a major contributor to many, if not all, diseases," according to a report in the Journal of Clinical Gastroenterology

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Glutathione is a tripeptide that is synthesized by forming one peptide bond between the gamma-carboxyl group of glutamate and the amino group of cysteine (forming gamma- glutamyl cysteine), and then by forming a second peptide bond between the carboxyl group of cysteine and the amino group of glycine