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GLP-1 ( , )

Adverse effects of gluten ingestion and advantages of gluten withdrawal in nonceliac autoimmune disease

Topics for Further Discussion Explore the role of GLP-1 and GIP, molecules known as incretins

this warrants ongoing monitoring No unexpected serious cardiovascular signals were identified during the limited Phase 2 follow-up period, though the trials were neither designed nor powered to assess cardiovascular outcomes, and longer-term data are not yet available At present, the overall safety profile appears broadly consistent with other GLP-1-based therapies, but definitive conclusions cannot be drawn until Phase 3 data and post-marketing surveillance are available

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