Fecal microbiota transplantation (FMT) shows great potential in treating refractory colitis, particularly for recurrent or refractory Clostridium difficile infections, where the core mechanism may involve the donor microbiotas reprogramming of host iron metabolism
The rate-limiting precursor for GSH synthesis is cysteine, which is imported into cells by system Xc-, a cystine and glutamate antiporter in the plasma membrane comprising xCT (solute carrier family 7 member 11) and solute carrier family 3 member 2
Furthermore, the microbiota optimizes dietary iron bioavailability by producing essential amino acids and SCFAs, thereby lowering the pH within the intestinal lumen
Microbial metabolite deoxycholic acid-mediated ferroptosis exacerbates high-fat diet-induced colonic inflammation
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Targeted delivery of probiotics and their metabolites, based on the pathological link between intestinal microbiota metabolites and ferroptosis, may help inhibit ferroptosis, correct microbiota dysregulation, and restore immune homeostasis, offering a promising precision intervention strategy to alleviate IBD inflammation
