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Designing a protocol that leverages both without creating negative feedback or desensitization is the hallmark of a well-thought-out scientific inquiry

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This, in turn, decreases T-cell activation and proliferation [92]

Additionally, the release of intercellular adhesion molecules (ICAM-1) and vascular cell adhesion molecules (VCAM-1) on endothelial cells enhances the adherence and extravasation of leukocytes into the inflamed tissue (Habas and Shang, 2018)

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