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As the authors point out, long-term proton pump inhibitor use is connected to serious side effects and increases the risk of some other potentially serious conditions such as Clostridium difficile associated diarrhea, osteoporosis, and vitamin or electrolyte malabsorption

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People with unmanaged diabetes, untreated sleep apnea, or significant cardiovascular disease should also stay away, as the peptide could make things worse

Other Pine Bark Extracts There is some evidence that pine bark extract may help improve circulation and chronic venous insufficiency, but be aware that some supplements are not like those used in most clinical trials