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Extensive research has been conducted in this area, and several studies have documented the impact of various GLMs on the risk of fractures in T2DM ( Denmark introduced glucagon-like peptide-1 receptor agonists (GLP-1 RA) and dipeptidyl peptidase 4 inhibitors (DPP-4i) in 2007, and since then, there has been a constant influx of novel medications belonging to these therapeutic classes ( Sodium-glucose co-transporter-2 (SGLT2) inhibitors are the more recent class of drugs approved as blood glucose-lowering agents ( Various authoritative organizations have endorsed dipeptidyl peptidase (DPP)-4 inhibitors as secondary treatment options for older individuals living with T2DM ( Research endeavors aimed at examining the impact of diverse antidiabetic medications on fracture risk often encounter challenges related to confounding factors and inadequate durations of follow-up ( Given these circumstances, the existing data are inadequate to justify the decision at present of the most suitable therapeutic strategies for elderly diabetics in routine clinical practice
