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SGLT2 inhibitors have been shown to reduce major adverse cardiovascular events (MACE, a composite endpoint of myocardial infarction, stroke and cardiovascular death) and hospitalization for heart failure in large clinical trials in patients with type 2 diabetes at high cardiovascular risk
Orandi : We do not get much added kidney benefit from GLP-1s for people who are already on dialysis, but they likely have cardiovascular benefit
doi:10.1021/acs.jmedchem.1c00565
How Ozempic and Similar Medications Affect Digestion Ozempic, Trulicity, Wegovy, Mounjaro and Rybelsus work by mimicking the hormone glucagon-like peptide-1 (GLP-1), which slows down food moving from the stomach to the intestines
And capsaicin, also known as a major agonist of TRPV1, activates sensory neurons and produces a burning pain sensation