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Iron modulators degrade FPN (the sole iron export protein) on macrophage surfaces, increasing intracellular iron content

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Phase 3 monotherapy results A post-hoc analysis of the phase 3 data showed cagrilintide 2.4 mg monotherapy produced 11.8% average body weight reduction versus 2.3% for placebo over 68 weeks

Stacked Protocol (Cagrilintide + Smglutd) Dose: 0.6 2.4 mg Cagrilintide + 0.25 2.4 mg Smglutd (= 2496 clicks) Duration: 12 20 weeks Frequency: Once weekly, co-administered Cycle Interval: 4 6 weeks off before repeating Goal / Description: Dual amylin and GLP-1 receptor activation studied for enhanced metabolic and weight outcomes