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Alcohol: Breaking down alcohol places a heavy metabolic burden on the liver

Thus, we could confirm that targeting the NADH:ubiquinone oxidoreductase complex by phenformin and the succinate dehydrogenase by atpenin A5 blocked viral replication in cell culture experiments with minimal cellular toxicity

10.1016/s1097-2765(02)00599-3 84 MederosM

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This regulatory effect of DMF was identified through NRF2-dependent and independent mechanisms with NRF2 binding to ARE motifs and increasing DNA 5hmC of individual gene regulatory regions involved in the TSS pathway, cystine uptake, and GSH generation

Cancers 16, 14641486