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Orally delivered semaglutide resulted in considerable weight reduction over 26 weeks in the PIONEER clinical trials, surpassing other GLP-1-RA medications

Cash-Pay Is Still the Only Way Many People Can Get GLP-1s Insurance issues mean that even people with obesity who could see a significant health boost from GLP-1s may find they have to pay out of pocket

They may be prescribed when medically appropriate and prepared by licensed, FDA-compliant compounding pharmacies that follow applicable state and federal standards

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In the long term, excessive sodium intake can lead to high blood pressure and increase the risk of heart disease, stroke, and obesity

Less common but serious: pancreatitis, gallbladder disease, kidney injury, hypoglycemia (with other diabetes meds), worsening diabetic retinopathy, and rare allergic reactions