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Proses pembentukan zat ini terjadi di hati, yakni organ yang bertanggung jawab atas detoksifikasi pada tubuh

A few common drugs that fall into this category include amlodipine (Norvasc), diltiazem (Cardizem), verapamil (Calan)

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However, it is a poorer precursor as it requires methyl ester modification for transport into the cell 37,38