JUDITH: I've had some side effects, mostly constipation and brain fog, but they're manageable with proper nutrition and hydration, which is critical on this drug
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Evaluation method Results were assessed using three methods: (1) SALT (Severity of Alopecia Tool) scoring, (2) blinded dermatologist evaluation of before/after photographs, and (3) AI-assisted assessment using ChatGPT
Interestingly, several fragment hits originating from our second XChem screen possess alternative groups to the sulfonic acid that interact with R131 and R102, which opens up opportunities to link and merge hit matter found across the TIN2 leucine and phenylalanine binding pockets