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Also, serum total protein in male animals was reduced (2000 and 3000 mg/kg) in the treated male rats while an elevated low density lipoprotein (3000 mg/kg) was obtained in female animals

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Moreover, we found that colistin-induced depolarization is sensitive to cyclosporin A, a potent inhibitor of mitochondrial cyclophilin D (CyPD), one of the components of the mPTP, whose expression and function are required for the onset of the permeability transition 49

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