Governance arrangements must be implemented specifically around accountability for health professionals, with a focus on training and evaluation of quality of practice
Given that GLP-1 agonists can cause gastroparesis, there is increased concern for ileus when the patient is taking an antipsychotic medication with a high ACB, such as Clozapine, Olanzapine, Quetiapinethe same medications for which we are wanting to manage metabolic side effect consequences
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In hepatocellular carcinoma models induced by DEN combined with either high-fat/high-carbohydrate or low-fat/low-carbohydrate diets, lean m/db mice, and MCD- or CDE-induced liver injuryas well as in human models, exenatide activation of the GLP-1RcAMPPKAEGFRSTAT3 pathway suppressed oncogenic signaling, limited tumor cell growth, and enhanced apoptosis, resulting in a marked reduction in tumor progression (Zhou et al., 2017)
Without a head-to-head trial, definitive superiority cannot be established
Some patients may qualify for a GLP-1 plan
