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The use of angiotensin-converting enzyme (ACE) inhibitors also mandates caution with ozone therapy [20, 21]

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a , Systemic administration of IFNAR1 Ab (40 mg/kg, i.p.) one hour prior to cartilage autoantibody injection prevented mechanical allodynia (von Frey filaments) and administration on day 22 and day 45 reversed established allodynia and hyperalgesia compared to isotype IgG1 group (n = 6 per group)

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This raises peri-procedural concerns regarding anesthesia/pulmonary aspiration risks, poor visibility, and the need for repeat procedures, all of which contribute to significant time, cost, and resource utilization burden