In healthy subjects exogenous IGF-1, like insulin, causes hypoglycemia and a transient decrease in free serum fatty acids
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[46] Kitano Y, Hashimoto S, Matsumoto H, et al
[9] The function of carnitine as a transmitter of fatty acids through the inner membrane of the mitochondria for use in the process of oxidation, facilitating the reabsorption of acetyl CoA, increasing the production of acetylcholine, increasing the production of phospholipids in cell membrane, and preventing the death of neural cells is some of the proposed mechanisms
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The mechanisms underlying IGF-1 LR3's anabolic effects involve activation of the PI3K/Akt/mTOR signaling pathway, which stimulates ribosomal protein S6 and translation initiation factors downstream of mTORC1, thereby enhancing protein synthesis
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