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Macrodosing pushes the medication to a level where appetite suppression, slowed gastric emptying, and insulin signaling are not just supportive, but central drivers of measurable change

Retatrutide is currently in Phase 3 clinical trials and is not FDA approved yet

For comparison, a separate study in The New England Journal of Medicine that compared tirzepatide and semaglutide over 72 weeks found people who took tirzepatide lost an average of 50 pounds or about 20.2 percent of their body weight

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This is called hyperglycemia and, if left unchecked, it can cause eye problems, kidney damage, nerve damage, and cardiovascular disease