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Methyl-group sparing Supplemental creatine can reduce endogenous creatine synthesis and therefore lower one major use of SAM-derived methyl groups

NaBPC157 (administered either in the ng or g/kg range, i.p.) significantly reduced the reactions in the writhing (inflammatory and non-inflammatory, prostaglandin-dependent and independent) and tail pinching tests

doi: 10.1016/S0167-4838(01)00147-9 53 ReimanE

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