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The "rapid reversal" group (approximately 10-15% of users) experiences concerning quick benefit loss within weeks of discontinuation, typically involving users who applied very high concentrations creating dependency-like patterns, possessed severe underlying skin conditions requiring ongoing treatment, experienced significant lifestyle or environmental stressors overwhelming skin resilience, discontinued abruptly without tapering from high-dose protocols, or had unrealistic perception inflation during treatment leading to exaggerated reversal perception

Then 125 l of brain homogenate were collected with 125 l of lysis buffer (made as previously described)

Alpha-Lipoic Acid (ALA) Alpha-lipoic acid is often called the "universal antioxidant" because it is both fat- and water-soluble

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Supplementary Table S1 listed antibodies used in this study