SGLT2 inhibitors and GLP-1s have trial-level evidence showing they slow kidney disease, reduce cardiovascular events, and extend life
Furthermore, in a mouse model of CKD-induced muscle atrophy, miR-29 was decreased in skeletal muscle [140], and exosome-mediated miR-29 transfer prevented muscle atrophy [141]
Formal human pharmacokinetic data on BPC-157 remain absent from published clinical literature as of 2026
Resveratrol inhibits collagen-induced platelet stimulation through suppressing NADPH oxidase and oxidative inactivation of SH2 domain-containing protein tyrosine phosphatase-2
The most common side effects of oral silymarin ingestion include:2 Abdominal pain/fullness Bloating Bowel changes Diarrhea Dyspepsia (indigestion) Flatulence Headache Nausea Pruritus (itching) Of note, there's at least one case report of more severe instances of the above, along with sweating, colicky pain, weakness, and collapse, in a 57-year-old woman after taking a milk thistle capsule
MDL 3094 is being heard in the Eastern District of Pennsylvania and involves lawsuits with common questions of fact including whether the manufacturers (Eli Lilly and Novo Nordisk) knew or should have known that their products cause severe gastrointestinal injuries such as gastroparesis
