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Head-to-head comparison (STEP 8) The STEP 8 trial provides direct side-effect comparison data: 1 Gastrointestinal adverse events: 84.1% with semaglutide vs 82.7% with liraglutide Treatment discontinuation due to adverse events: 13.5% with semaglutide vs 27.6% with liraglutide While the overall rate of gastrointestinal side effects was similar, liraglutide had a substantially higher discontinuation rate

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Semaglutide is sometimes used in combination with metformin, increasing the anti-inflammatory and anti-fibrotic effects [2,8], and significantly improving liver inflammation and fibrosis in people with non-alcoholic fatty liver disease [8]

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Now rebranded as the Ozempic pill, the updated formulation is available in different strengths of 1.5 mg, 4 mg, and 9 mg