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Our study found that ascorbate was related with higher chances of ALS by using MR study, which was consistent with some previous research results

PloS One (2017) 12:e0179889

iScience 23 , 101252 (2020)

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The results of molecular docking and western blot in this study suggest that ATX may directly act on AMPK and SIRT1, providing a potential mechanistic hypothesis for the observed neuroprotective effects

NLRP3 activation and inflammation are associated with numerous disorders, suggesting an important underlying role for environmental factors such as oxidative stress which interact with genetic factors to determine individual risk