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Additionally, apoptotic neutrophils and thymocytes exhibited similar lipidomic features, and their efferocytosis resulted in a higher accumulation of free fatty acids (FFAs) in macrophages, as well as the upregulation of genes associated with pathways activated by fatty acids and cholesterol, including PPAR and LXR

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In particular, cocaine treatment in mice has been shown to cause a bidirectional loss of activity-dependent synaptic plasticity in the nucleus accumbens core, which is a defect in both LTP and LTD of excitatory synaptic transmission [114]

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