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The need for frequent adjustments increases the risks of irritation and ulceration which are drawbacks of this therapy

Finally, if animal precondition occurs, modification of defensive process occurs before its initiation much like in the classic cytoprotection studies (note, standard cytoprotective agents would act only when given before alcohol (1-3))

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One patient achieved 33 percent total body weight loss over 115 weeks, but 91.2 percent of that weight loss came from fat, with only 8.7 percent from lean tissue