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However, mechanistic investigations reveal that this advantage varies by individual, underlining the importance of accurate immunophenotyping to predict who may benefit from cytokine-targeted therapy

J Am Chem Soc 132:66326633 Servillo L, Castaldo D, Casale R, DOnofrio N, Giovane A, Cautela D, Balestrieri ML (2015) An uncommon redox behavior shed light on the cellular antioxidant properties of ergothioneine

However, it requires strict adherence to dosing instructions to increase absorption and efficacy

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That 3% threshold is the standard clearance benchmark