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Combining imatinib with indomethacin, a chemical inhibitor of AKR1C3, significantly prolonged mouse survival and reduced splenomegaly, indicating that AKR1C3 suppression has the potential to enhance imatinib treatment

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Chi A, Valencia JC, Hu ZZ, Watabe H, Yamaguchi H, Mangini NJ, et al

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Chem Biol Interact 327:109181 Fu X et al (2020) Overexpression of Nrf2 protects against lipopolysaccharide and cerulein-induced pancreatitis in vitro and in vivo