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Sample size calculation A sample size calculation was conducted using the 24-week primary ITT analysis from our BARI-OPTIMISE trial 13 and the results of the Davies et al

It is also distinct from dose reduction after reaching maintenance

Moreover, taking higher amounts of a substance doesnt always make it more potent

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While Ozempic generally does not cause clinically significant hypotension in normotensive individuals when used as monotherapy, patients should be aware that dehydration from gastrointestinal side effects could potentially lead to reduced blood pressure in some cases