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According to the note, the TGA has received reports of people experiencing severe inflammation, allergic reactions involving hospitalisation, blurred vision, muscle injuries and insomnia

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GLP-1 receptor agonists such as semaglutide reshaped obesity pharmacology by curbing appetite and improving glycemic control, but researchers hypothesized that recruiting the glucagon receptor could add a complementary axis increased energy expenditure and enhanced hepatic fat handling that a pure GLP-1 agonist cannot reach

2 The APA article notes that many patients discontinue treatment within a year because of side effects, cost, access issues, or other challenges, but this source does not establish mental distress as a uniform or primary reason across all patients

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