This represents an opportunity to reduce opioid prescribing and facilitate tapering in appropriate patients
10.1038/cr.2013.168 37 GaoX.LuY.FangL.FangX.XingY.GouS.et al (2013)
AOD-9604 , representing only amino acids 176-191 of growth hormones 191-amino acid structure, does not contain the regions (Sites 1 and 2) responsible for receptor binding
The slow titration (125 mcg weeks 1-4, then 250 mcg weeks 5-8) mimics FDA-approved protocols that emphasize gradual increases for tolerability
To date, only a limited number of medications (disulfiram, acamprosate, and naltrexone) have been approved for the treatment of AUD by the Food and Drug Administration (FDA) and the European Medicines Agency (EMA)
List prices have been reported in the range of USD 1,0001,100 per month before insurance or manufacturer discount programmes