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Populations of particular concern based on mechanism and the absence of human data include: individuals with active or suspected malignancy (pro-angiogenic preclinical profile)

166 , 167 , 168 The molecular defect in these cases has been associated with different missense mutations

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Acylcarnitines have also been shown to be involved in the phospholipid and fatty acid turnover of the nerve membrane, affecting its fluidity and membrane protein activity [113]