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Both prophylactic and therapeutic administration of Cur-NLCs effectively counteracted A-mediated cognitive dysfunction and neuronal toxicity, demonstrating their robust neuroprotective activity (146)

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They discovered that the synthesized COF-618-Cu adopts a distinct staggered stacking configuration ( Figure 4B )

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As such, it is apparent that additional experimentation focusing on genomics, environmental/nutritional components and their crosstalk is warranted to determine the causal factor(s) that reduce both cystine and selenoprotein levels in children affected with konzo to unravel the biological mechanism behind this disease