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Total flavonoids from rhizoma Drynariae (gusuibu) alleviates diabetic osteoporosis by activating BMP2/smad signaling pathway

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For patients with mild disease or in the early stage and intolerant to drug side effects, combined treatment is not recommended, but single drug treatment should be selected

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And then the third element was that the study design pre-specified that we would have dose escalation of tirzepatide, and the dose would be escalated up to a maximally tolerated dose of 15 milligrams every week