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Increasing beyond 300 mcg adds side effects without proportional sleep improvement

Lastly, although it has been shown that GABA is an HDACi in a neuroblastoma cell line (Xing et al., 2019), in our hands, GABA does not inhibit HDACs to a detectable level in colonic epithelial cells (unpublished)

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Probiotics achieve these effects by upregulating tight junction protein expression, modulating epithelial cell apoptosis, and influencing immune signaling pathways to enhance barrier resilience

Notably, the ALKIVIA study also demonstrated positive phase II/III results for VYVGART Hytrolu within idiopathic inflammatory myopathies, triggering its further development within this indication [253], for which efgartigimod is the FcRn antagonist with the most advanced clinical program as of January 2025