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Vitamin B12 works with folate and produces a compound S-adenosylmethionine that creates and regulates hormones, helps regulate moods and the immune system

This acylation blocks DPP-IV and extends the half-life from 7 minutes to 2660 minutes

In 2014, Yang et al

Collectively, the results from our in vivo rat IVD degenerative model showed that the injection of DFbs or the L929 murine fibroblastic cell line into the IVDs following needle puncture could maintain IVD height, reduce osteophyte formation in the adjacent vertebral bodies, inhibit adjacent end-plate degeneration, and improve the nuclear magnetic resonance signals of the IVDs

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Not suitable for people with a history of blood clots or stroke, as it may increase the risk of recurrence