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Saxenda, being an older GLP-1 medication, has some downsides compared to newer GLP-1 medications

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References Ast J, Arvaniti A, Fine NHF, Nasteska D, Ashford FB, Stamataki Z, Koszegi Z, Bacon A, Jones BJ, Lucey MA, Sasaki S, Brierley DI, Hastoy B, Tomas A, DAgostino G, Reimann F, Lynn FC, Reissaus CA, Linnemann AK, DEste E, Calebiro D, Trapp S, Johnsson K, Podewin T, Broichhagen J, Hodson DJ

Very little drug is absorbed across the stomach wall

Clade 1 and 2 GS-like genes are expressed (dark staining) throughout the punctate digestive system and expression is absent from the gland cells