In addition to the reduced glutathione (GSH)/GPX4 axis, ferroptosis is inhibited by the ferroptosis suppressor protein 1 (FSP1)/coenzyme Q10 (CoQ10), GTP cyclohydrolase 1 (GCH1)/tetrahydrobiopterin (BH4), and dihydroorotate dehydrogenase (DHODH)/CoQH2 pathways [162]
5-7 One key misunderstanding is that this is a disease of just lack of willpower, when in fact there is underlying biology that may impede people with obesity from losing weight and keeping it off
This finding could have both pharmacological and biotechnological applications
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