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Tirzepatide vs Semaglutide: Mechanism Differences The main distinction in tirzepatide vs semaglutide lies in receptor activation: Feature Zepbound Wegovy Receptors GLP-1 + GIP GLP-1 only Dosing Weekly injection Weekly injection Metabolic pathway Dual incretin effect Single incretin effect For broader GLP-1 context, see: GLP-1 Weight Loss 2026: Complete Medical Guide Effectiveness Comparison Clinical trials suggest higher average percentage weight reduction with tirzepatide compared to semaglutide in some populations

Regular follow-up appointments with your healthcare team are crucial

While skin sensitivity is not listed among the most common adverse effects of semaglutide, dermatological reactions have been reported in clinical practice and post-marketing surveillance

GLP-1 agonists and their potential for delayed gastric emptying may be associated with an increased risk of regurgitation and aspiration of gastric contents during general anesthesia and deep sedation

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Some patients notice a slight uptick in appetite during that gap week, but keep your eating habits consistent and you'll bridge it without issues