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OCTN2 is differentially expressed in various tissues and plays a major role in regulating carnitine levels within these tissues

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Additional information Associate Editor Yihua Bei oversaw the review of this article

Common supplemental forms include: L-arginine HCL : The standard hydrochloride form L-arginine alpha-ketoglutarate (AAKG) : Popular in sports supplements Arginine nitrate : A newer form combining arginine with nitrate for potentially enhanced effects Beyond its role in nitric oxide production, L-arginine participates in protein synthesis, ammonia detoxification, and hormone secretion

Interestingly, after a week-long suppression of the gut microbiota with oral broad-spectrum antibiotics cocktail, a rechallenge with oral d 9 -BB showed complete suppression of d 9 -TMAO formation in subjects, confirming gut microbiotadependent conversion of BB into TMAO (Figure 2A, open circles)