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In addition, peroxide GPXs can also recycle peroxidized free polyunsaturated fatty acids and phospholipid hydroperoxides

In these latter cases, a betaine and/or methionine supplement should be given in combination with folinic acid or 5-methylTHF (Table 2)

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Here, we have utilized liver-specific overexpression of cation transport regulator homolog 1 (Chac1), a recently identified intracellular GSH-degrading enzyme, to induce hepatic GSH depletion during MASLD progression

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